大鼠和人类胚胎及出生后血清中含有一种有效的雌激素与大鼠甲胎蛋白相互作用的内源性竞争物。

Rat and human embryo and post-natal sera contain a potent endogenous competitor of estrogen-rat alpha-fetoprotein interactions.

作者信息

Benassayag C, Vallette G, Delorme J, Savu L, Nunez E A, Jayle M F

出版信息

Steroids. 1977 Dec;30(6):771-85. doi: 10.1016/s0039-128x(77)80023-8.

DOI:10.1016/s0039-128x(77)80023-8

PMID:77070

Abstract

A highly active inhibitor of the binding of estrone and estradiol-17beta to rat alpha-fetoprotein is demonstrated for the first time in embryo, immature and adult rat sera as well as in fetal and adult human sera. The competitive character and the narrow specificity of this inhibition effect is shown. The major compound responsible for this activity is isolated by successive column Sephadex LH20 and thin layer chromatography: it is characterized as a nonpolar, nonphenolic, dialysable and thermostable substance, unreactive towards anti-estrone and anti-estradiol-17beta antibodies. The possible biological role of an endogenous non-estrogen ligand of rodent fetoproteins is discussed.

摘要

首次在胚胎、未成熟和成年大鼠血清以及胎儿和成年人类血清中证实了一种对雌酮和雌二醇-17β与大鼠甲胎蛋白结合具有高度活性的抑制剂。显示了这种抑制作用的竞争性特征和狭窄的特异性。通过连续的Sephadex LH20柱和薄层色谱法分离出负责这种活性的主要化合物：其特征为非极性、非酚类、可透析且热稳定的物质，对抗雌酮和抗雌二醇-17β抗体无反应。讨论了啮齿动物甲胎蛋白内源性非雌激素配体可能的生物学作用。

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Steroids. 1977 Dec;30(6):771-85. doi: 10.1016/s0039-128x(77)80023-8.

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引用本文的文献

1

The serum competitor of oestrogen--rat alpha 1-foetoprotein interactions. Identification as a mixture of non-esterified fatty acids.雌激素的血清竞争物——大鼠α1-甲胎蛋白的相互作用。鉴定为非酯化脂肪酸混合物。

Biochem J. 1980 Jun 1;187(3):851-6. doi: 10.1042/bj1870851.

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