Stass S A, Pui C H, Melvin S, Rovigatti U, Williams D, Motroni T, Kalwinsky D, Dahl G V
Br J Haematol. 1984 Jul;57(3):413-21. doi: 10.1111/j.1365-2141.1984.tb02915.x.
The presence of greater than 3% Sudan black B (SBB) positivity in leukaemic blasts has been considered diagnostic of acute non-lymphocytic leukaemia (ANLL). A rare report has indicated that this finding may not be specific for ANLL. In order to determine whether SBB could be found in acute lymphoblastic leukaemia (ALL) the data on 350 patients with newly diagnosed ALL were reviewed. Six patients (1.6%) were found to have 5% or greater SBB positive blasts. The diagnosis of ALL was supported by morphology, cytochemistries, immunologic markers, therapeutic response, and in one case immunoglobulin gene rearrangement. It is important to recognize the fact that SBB is not specific for AML and may be found in the blasts of patients with ALL.
白血病原始细胞中苏丹黑B（SBB）阳性率大于3%被认为是急性非淋巴细胞白血病（ANLL）的诊断依据。一份罕见报告指出，这一发现可能并非ANLL所特有。为了确定急性淋巴细胞白血病（ALL）中是否能检测到SBB，我们回顾了350例新诊断ALL患者的数据。6例患者（1.6%）的原始细胞SBB阳性率为5%或更高。ALL的诊断得到了形态学、细胞化学、免疫标志物、治疗反应的支持，其中1例患者还进行了免疫球蛋白基因重排检测。必须认识到，SBB并非AML所特有，在ALL患者的原始细胞中也可能检测到。
