Jostell K G, Agurell S, Hollister L E, Wermuth B
Clin Pharmacol Ther. 1978 Feb;23(2):181-7. doi: 10.1002/cpt1978232181.
Chlormethiazole administered orally to patients in mild degrees of alcohol withdrawal was generally rapidly absorbed, showed a rapid distributive phase, and had an elimination phase 1 1/2 of 2.6 to 4.7 hr. The plasma concentrations of drug attained following higher oral doses were greater than is usually the case with augmentation of dose. Intravenously infused chlormethiazole in similar patients produced relatively high plasma concentrations of the drug, with distributive and eliminative 1 1/2 similar to those of oral doses. These pharmacokinetic patterns in alcoholic patients more closely resemble those previously reported for normal young subjects than they do for normal aged subjects.
口服氯美噻唑给轻度酒精戒断患者，药物通常迅速吸收，呈现快速分布相，消除半衰期为2.6至4.7小时。较高口服剂量后达到的血浆药物浓度高于通常随剂量增加的情况。在类似患者中静脉输注氯美噻唑产生相对较高的血浆药物浓度，分布和消除半衰期与口服剂量相似。酒精性患者的这些药代动力学模式与先前报道的正常年轻受试者的模式比与正常老年受试者的模式更相似。
