乙醇给药对氯美噻唑处置和消除的影响。
The effect of ethanol administration on the disposition and elimination of chlormethiazole.
作者信息
Bury R W, Desmond P V, Mashford M L, Westwood B, Shaw G, Breen K J
出版信息
Eur J Clin Pharmacol. 1983;24(3):383-5. doi: 10.1007/BF00610059.
Acutely administered ethanol has been shown to inhibit the hepatic metabolism of a number of drugs. Ethanol might be expected to decrease the first-pass extraction of chlormethiazole leading to higher blood levels of this high clearance sedative frequently used in the management of alcoholic patients. Chlormethiazole has a narrow therapeutic index and the unexpected deaths reported in alcoholics taking this drug may have been due to an effect of ethanol on the metabolism of chlormethiazole. However in this study, acutely administered ethanol maintained at levels around 22 mmol/l had no significant effect on the disposition or elimination of either daily or intravenously administered chlormethiazole.
急性给予乙醇已被证明可抑制多种药物的肝脏代谢。乙醇可能会降低氯美噻唑的首过提取率，导致这种常用于治疗酒精性患者的高清除率镇静剂的血药浓度升高。氯美噻唑的治疗指数较窄，服用该药的酗酒者中报告的意外死亡可能是由于乙醇对氯美噻唑代谢的影响。然而，在本研究中，急性给予乙醇并维持在约22 mmol/l的水平对每日或静脉给予氯美噻唑的处置或消除没有显著影响。
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