Matsuura M
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1984;78(1):111-6.
Relaxation of catch tension by 8-bromo-cyclic GMP in the ABRM of Mytilus was blocked in the presence of mersalyl and was markedly reduced after treatment of the muscle with alpha-methyldopa. In the muscle depolarized by 540 mM KCl + 5 mM EGTA solution, 8-bromo-cyclic GMP could not relax Ca-contracture. Hexylamine and phenylethylamine, which are assumed to relax the catch acting on relaxing nerve terminals, could not relax the contracture either. Serotonin and dopamine, which are known to relax the catch acting directly on the muscle fibre membrane, could relax it. In the muscle depolarized by 250 mM KCl + 5 mM EGTA solution, all of the cyclic nucleotides tested (cyclic AMP, cyclic GMP and their analogues), serotonin and dopamine relaxed Ca-contracture, but hexylamine and phenylethylamine did not relax the contracture. The possibilities of the involvement of cyclic GMP in the presynaptic and postsynaptic relaxing mechanisms in the ABRM are discussed.
在贻贝的副闭壳肌中，8-溴环鸟苷酸引起的捕获张力松弛在汞撒利存在时受到阻断，并且在用α-甲基多巴处理肌肉后显著降低。在由540 mM氯化钾+5 mM乙二醇双乙胺四乙酸溶液去极化的肌肉中，8-溴环鸟苷酸不能松弛钙挛缩。己胺和苯乙胺被认为可松弛作用于松弛神经末梢的捕获，但它们也不能松弛挛缩。已知5-羟色胺和多巴胺可松弛直接作用于肌纤维膜的捕获，它们能够松弛挛缩。在由250 mM氯化钾+5 mM乙二醇双乙胺四乙酸溶液去极化的肌肉中，所有测试的环核苷酸（环磷酸腺苷、环鸟苷酸及其类似物）、5-羟色胺和多巴胺均可松弛钙挛缩，但己胺和苯乙胺不能松弛挛缩。本文讨论了环鸟苷酸参与副闭壳肌突触前和突触后松弛机制的可能性。
