Mullen P W
Clin Pharmacol Ther. 1978 Feb;23(2):228-32. doi: 10.1002/cpt1978232228.
A simple, new technique (the direct linear plot) for predicting steady-state serum phenytoin concentrations is described. Although no calculations are required, reliable estimates (comparable with those derived by computer) of the Michaelis-Menten parameters can be readily determined and used graphically to predict the individualized dose required to achieve a desired serum concentration.
