溶酶体亲和胺对自然杀伤细胞和细胞毒性T淋巴细胞的自发及干扰素增强的细胞溶解作用。
Action of lysosomotropic amines on spontaneous and interferon enhanced NK and CTL cytolysis.
作者信息
Ausiello C, Sorrentino V, Ruggiero V, Rossi G B
出版信息
Immunol Lett. 1984;8(1):11-5. doi: 10.1016/0165-2478(84)90097-x.
PMID:6204935
Abstract
Cell-mediated cytotoxicities, such as natural killer (NK) and T-dependent cytotoxic (CTL) activities, are inhibited to the same extent by lysosomotropic amines, even when interferon is added to cultures to enhance lysis. It is postulated that the amines block steps common to spontaneous and IFN-enhanced NK and CTL lytic mechanisms.
摘要
细胞介导的细胞毒性，如自然杀伤（NK）和T细胞依赖性细胞毒性（CTL）活性，即使在向培养物中添加干扰素以增强裂解作用时，也会被溶酶体亲和胺以相同程度抑制。据推测，这些胺类阻断了自发的以及干扰素增强的NK和CTL裂解机制共有的步骤。
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