糖皮质激素对自然杀伤细胞活性的体外作用特性研究。
Characterization of the in vitro effects of glucocorticosteroids on NK cell activity.
作者信息
Pedersen B K, Beyer J M
出版信息
Allergy. 1986 Apr;41(3):220-4. doi: 10.1111/j.1398-9995.1986.tb00303.x.
Abstract
The NK cell activity of mononuclear cells as well as monocyte-depleted, Percoll-fractionated, NK cell-enriched effector cells against K 562 target cells was inhibited by methylprednisolone (MP) and hydrocortisone (HC) in a dose-dependent manner. The effector/target cell conjugate formation was studied in a single cell agarose assay, and it was shown that MP and HC partly inhibited the NK cell activity by inhibition of the adhesion of effector cells to target.
摘要
甲基强的松龙（MP）和氢化可的松（HC）以剂量依赖的方式抑制单核细胞以及去除单核细胞、经Percoll梯度分离、富含NK细胞的效应细胞针对K 562靶细胞的NK细胞活性。在单细胞琼脂糖试验中研究了效应细胞/靶细胞共轭体的形成，结果表明MP和HC通过抑制效应细胞与靶细胞的黏附而部分抑制NK细胞活性。
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