Bluestone J A, Potter T A, Chatterjee-Hasrouni S, Rajan T V
J Immunol. 1984 Sep;133(3):1168-73.
Reciprocal Ld structural mutants have been isolated from a somatic cell line. Testing of allogeneic CTL clones on these mutants suggests that the majority of CTL clones recognize determinants different from those that elicit antibody production. Of 36 CTL clones tested, only three clones appeared to recognize a determinant that was related to the negatively selected serologic determinant. However, mAb blocking studies suggest that inhibition of CTL activity by anti-H-2 mAb does not necessarily reflect the fine specificity of the CTL activity.
已从一个体细胞系中分离出相互的Ld结构突变体。对这些突变体进行的同种异体CTL克隆检测表明，大多数CTL克隆识别的决定簇与引发抗体产生的决定簇不同。在检测的36个CTL克隆中，只有三个克隆似乎识别与阴性选择的血清学决定簇相关的决定簇。然而，单克隆抗体阻断研究表明，抗H-2单克隆抗体对CTL活性的抑制不一定反映CTL活性的精细特异性。
