Dohi Y, Higasa M, Nishimura M, Hirayama A, Takagaki Y, Yamada K, Inoue K, Shinka S
J Immunol. 1985 Jul;135(1):47-52.
Cytotoxic T lymphocytes (CTL) specific for self immunoglobulin (Ig) determinants on B lymphocytes were successfully generated. These CTL were induced with stimulator B hybridoma cells bearing self Ig determinants in responders compatible with the stimulators in H-2 antigens but disparate in minor H antigens. Their specificities were directed toward the idiotype and probably the allotype structures of Ig receptors on stimulator B cells. However, no CTL specific for Ig structures other than the idiotype and the allotype were detected. These data indicate the presence of specific precursor CTL for self B cell clones and suggest the possible development and function of these CTL in certain situations.
成功产生了针对B淋巴细胞上自身免疫球蛋白（Ig）决定簇的细胞毒性T淋巴细胞（CTL）。这些CTL是用携带自身Ig决定簇的刺激B杂交瘤细胞在与刺激细胞H-2抗原相容但次要H抗原不同的应答细胞中诱导产生的。它们的特异性针对刺激B细胞上Ig受体的独特型，可能还有同种异型结构。然而，未检测到针对独特型和同种异型以外的Ig结构的CTL。这些数据表明存在针对自身B细胞克隆的特异性前体CTL，并提示这些CTL在某些情况下可能的发育和功能。
