Nishida T, Sugiyama T, Oda T, Tazaki T, Yakushiji M, Kato T
Nihon Sanka Fujinka Gakkai Zasshi. 1984 Jul;36(7):1095-9.
A case of ovarian immature teratoma containing glioblastoma element with increased serum alpha fetoprotein (AFP) is demonstrated. In spite of a series of postoperative chemotherapeutic programs reported to be effective against gonadal germ cell tumors, the patient's condition continued to worsen even though the level of AFP had decreased to the normal range after the first line therapy with vincristine, actinomycin D and cyclophosphamide. The serum AFP titer in this case was unreliable as a tumor marker. Histologic examination of recurrent and metastatic tumors obtained at autopsy showed that other teratomatous tissues were widely infiltrated by a proliferated glioblastoma element. When considering the prognosis of ovarian immature teratoma, it is important to realize the aggressive potential of glioblastoma multiforme as a component.
本文展示了一例含有胶质母细胞瘤成分的卵巢未成熟畸胎瘤，其血清甲胎蛋白（AFP）升高。尽管有一系列术后化疗方案据报道对性腺生殖细胞肿瘤有效，但患者病情仍持续恶化，即便在一线使用长春新碱、放线菌素D和环磷酰胺治疗后AFP水平已降至正常范围。该病例中血清AFP滴度作为肿瘤标志物并不可靠。尸检时获取的复发和转移肿瘤的组织学检查显示，其他畸胎瘤组织被增殖的胶质母细胞瘤成分广泛浸润。在考虑卵巢未成熟畸胎瘤的预后时，认识到多形性胶质母细胞瘤作为其组成部分的侵袭潜能很重要。
