Li Z G, Wu Q Y
J Theor Biol. 1984 Jun 21;108(4):645-61.
According to the analysis of the chromosomal genes which act in development, we advance a model of gene action in development. In this model, the development is regarded as the programming action of different gene groups. The action of each and every gene group will activate the next gene group and make a self-inhibition. Therefore, the activation and inhibition of genes is a chain reaction during development; it is unlikely that the action of genes is entirely from inhibition to respective activation (Morgan model, 1934) or entirely from activation to respective inhibition (Caplan-Ordhal model, 1978). We use this model to explain some biological problems, such as development and differentiation, senescence and the cancer. According to our model, development and differentiation are not the same thing, senescence is the self-inhibition of the last gene group in somatic cells and the oncogene is the connexion gene in the programming action of gene groups.
