Department of Genetics, Hebei Medical University, Hebei Key Lab of Laboratory Animal, 361 Zhongshan East Road, Shijiazhuang 050017, Hebei Province, China.
Department of Genetics, Hebei Medical University, Hebei Key Lab of Laboratory Animal, 361 Zhongshan East Road, Shijiazhuang 050017, Hebei Province, China; Clinical Laboratory, The Second Hospital of Tangshan, 21 North Jianshe Road, Tangshan 063000, Hebei Province, China.
Ageing Res Rev. 2014 Jan;13:46-54. doi: 10.1016/j.arr.2013.11.001. Epub 2013 Nov 18.
Aging is a common characteristic of multicellular eukaryotes. Copious hypotheses have been proposed to explain the mechanisms of aging, but no single theory is generally acceptable. In this article, we refine the RNA population gene activating model (Lv et al., 2003) based on existing reports as well as on our own latest findings. We propose the RNA population model as a genetic theory of aging. The new model can also be applied to differentiation and tumorigenesis and could explain the biological significance of non-coding DNA, RNA, and repetitive sequence DNA. We provide evidence from the literature as well as from our own findings for the roles of repetitive sequences in gene activation. In addition, we predict several phenomena related to aging and differentiation based on this model.
衰老是多细胞真核生物的共同特征。人们提出了大量假说来解释衰老的机制，但没有一个单一的理论被普遍接受。在本文中，我们根据现有报道和我们自己的最新发现，对基于 RNA 群体基因激活模型（Lv 等人，2003）进行了改进。我们将 RNA 群体模型作为一种衰老的遗传理论。该新模型也可应用于分化和肿瘤发生，并能解释非编码 DNA、RNA 和重复序列 DNA 的生物学意义。我们根据文献以及我们自己的发现提供了重复序列在基因激活中作用的证据。此外，我们还根据该模型预测了与衰老和分化相关的几种现象。
