Cohen T J
Pacing Clin Electrophysiol. 1984 Jul;7(4):671-7. doi: 10.1111/j.1540-8159.1984.tb05595.x.
Physiologic control of heart rate may be limited by sinus node injury or congenital conduction defects. Control theory may be applied to restore physiologic rate control. Mean right atrial pressure is a likely candidate for incorporation into an artificial control system because of its: (1) stability at rest; (2) tendency to increase during exertion in the rate-limited heart; (3) ability to decrease with increasing heart rate in the rate-limited heart; and (4) accessibility for measurement via the transvenous route. A theoretical right atrial pressure feedback heart rate control system is presented; applications to physiologic pacing of patients with sick sinus syndrome, rate control of the transplanted heart, and pump frequency control of the total artificial heart are discussed.
心率的生理控制可能会受到窦房结损伤或先天性传导缺陷的限制。控制理论可用于恢复生理心率控制。平均右心房压力有可能被纳入人工控制系统,因为它具有以下特点:(1)静息时稳定;(2)在心率受限的心脏中运动时倾向于升高;(3)在心率受限的心脏中随心率增加而降低的能力;(4)可通过经静脉途径进行测量。本文提出了一种理论上的右心房压力反馈心率控制系统;并讨论了其在病态窦房结综合征患者的生理性起搏、移植心脏的心率控制以及全人工心脏的泵频率控制中的应用。