Furuhashi N, Tachibana Y, Kono H, Shinkawa O, Takahashi T, Suzuki M
Tohoku J Exp Med. 1984 May;143(1):47-51. doi: 10.1620/tjem.143.47.
The levels of human placental lactogen (hPL), beta-human chorionic gonadotropin (beta-hCG), unconjugated estriol (UE3) and total estriol (TE3) were measured radioimmunologically in women along their course of pregnancy. The serum hPL and beta-hCG levels were relatively constant in uncomplicated pregnancy, while UE3 and TE3 significantly rose towards 41 weeks of gestation. There were positive correlations between hPL and beta-hCG (n = 49, r = 0.737, p less than 0.001), and between UE3 and TE3 (n = 49, r = 0.904, p less than 0.0001). The ratios of placental hormones to estriol showed moderate declines towards 41 weeks of gestation. These data suggest that the fetal adrenal function increased toward the term, while the placental peptide hormones decrease or remain unchanged. Determination of serum unconjugated estriol was found to be convenient and useful for monitoring the fetoplacental function.
在孕期不同阶段，对女性体内人胎盘催乳素（hPL）、β-人绒毛膜促性腺激素（β-hCG）、游离雌三醇（UE3）和总雌三醇（TE3）水平进行放射免疫测定。在无并发症的妊娠中，血清hPL和β-hCG水平相对稳定，而UE3和TE3在妊娠41周时显著升高。hPL与β-hCG之间存在正相关（n = 49，r = 0.737，p < 0.001），UE3与TE3之间也存在正相关（n = 49，r = 0.904，p < 0.0001）。胎盘激素与雌三醇的比值在妊娠41周时呈适度下降。这些数据表明，胎儿肾上腺功能在足月时增强，而胎盘肽类激素减少或保持不变。发现测定血清游离雌三醇对监测胎儿-胎盘功能方便且有用。
