Fehér E, Léránth C, Williams T H
Acta Morphol Hung. 1984;32(1):23-9.
Substance P containing perikarya and processes were identified by electron microscopic immunocytochemistry in the rat small intestine. The labelled perikarya possessed a cytoplasm of high electron density rich in organelles most of which contained numerous 80 to 130 nm large granulated vesicles. Labelled processes were found in pre- and postsynaptic positions. The presynaptic terminals contained 80 to 130 nm granular vesicles and 30 to 40 nm clear vesicles. These findings provide a morphological basis for the assumption that the peptide substance P may act as a transmitter and exerts postsynaptic effect on other intrinsic neurons and that the labelled cell bodies are links to a local neuronal circuit in the small intestine.
通过电子显微镜免疫细胞化学方法在大鼠小肠中鉴定出含有P物质的核周体和突起。标记的核周体具有高电子密度的细胞质，富含细胞器，其中大多数含有许多直径为80至130nm的大颗粒囊泡。在突触前和突触后位置均发现了标记的突起。突触前终末含有80至130nm的颗粒囊泡和30至40nm的清亮囊泡。这些发现为以下假设提供了形态学依据：肽类物质P可能作为一种递质，对其他内在神经元发挥突触后效应，并且标记的细胞体是小肠局部神经回路的连接点。
