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Routine amniotic fluid alpha-fetoprotein measurement in 34,000 pregnancies.

作者信息

Crandall B F, Matsumoto M

出版信息

Am J Obstet Gynecol. 1984 Aug 1;149(7):744-7. doi: 10.1016/0002-9378(84)90115-7.

DOI:10.1016/0002-9378(84)90115-7
PMID:6205588
Abstract

Of 34,000 initial amniotic fluid samples, 0.7% had an alpha-fetoprotein level greater than or equal to +3 SD above the mean. The risk of an open neural tube defect or other serious fetal abnormality was 60% when alpha-fetoprotein levels measured greater than or equal to +3 and 86% for levels greater than or equal to +5 SD. In this series there were 72 open neural tube defects, and all were identified. The true false positive rate was 0.9 per 10,000 cases screened.

摘要

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