Grönblad M, Liesi P, Korkala O, Karaharju E, Polak J
Anat Rec. 1984 Jul;209(3):297-9. doi: 10.1002/ar.1092090306.
Nerves exhibiting substance P-like immunoreactivity were demonstrated in the human periosteum. A network of nerves showing substance P-like immunoreactivity was seen in the periosteum, while finer strands of immunoreactive nerve fibers were present immediately beneath the surface of the periosteum. Enkephalin-like immunoreactivity was also studied but could not be demonstrated. Substance P has previously been suggested to be involved in the mediation of the sensation of pain. The clinically observable marked pain sensitivity of periosteal tissue might be explained by the peptidergic nerves described in this paper.
在人类骨膜中证实了存在显示P物质样免疫反应性的神经。在骨膜中可见显示P物质样免疫反应性的神经网络，而在骨膜表面下方紧邻处存在更细的免疫反应性神经纤维束。还研究了脑啡肽样免疫反应性，但未证实其存在。先前有人提出P物质参与疼痛感觉的介导。本文所述的肽能神经可能解释了骨膜组织临床上可观察到的明显疼痛敏感性。
