局部用吲哚美辛对角膜新生血管形成及前列腺素E2水平的影响。
Topical indomethacin effect on neovascularisation of the cornea and on prostaglandin E2 levels.
作者信息
Frucht J, Zauberman H
出版信息
Br J Ophthalmol. 1984 Sep;68(9):656-9. doi: 10.1136/bjo.68.9.656.
Abstract
The effect of indomethacin 1% drops against a placebo (NaCl 0.9% solution) was tested in rabbits' corneas injured by a standardized chemical burn. The corneas treated with indomethacin 1% had less neovascularisation and a much smaller increase in the PGE2 levels as compared with the control fellow eyes treated with a placebo. It appears that indomethacin 1% drops have a clear effect on the inflammatory response of the cornea and deserve a clinical trial in selected patients suffering from corneal inflammatory changes.
摘要
在经标准化化学烧伤的兔角膜中，测试了1%吲哚美辛滴眼液相对于安慰剂（0.9%氯化钠溶液）的效果。与用安慰剂治疗的对侧对照眼相比，用1%吲哚美辛治疗的角膜新生血管较少，且前列腺素E2水平升高幅度小得多。看来1%吲哚美辛滴眼液对角膜炎症反应有明显作用，值得在患有角膜炎症变化的特定患者中进行临床试验。
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