吲哚美辛对眼组织中前列腺素合成酶系统的抑制作用。
Inhibition of the prostaglandin synthetase systems in ocular tissues by indomethacin.
作者信息
Bhattacherjee P, Eakins K E
出版信息
Br J Pharmacol. 1974 Feb;50(2):227-30. doi: 10.1111/j.1476-5381.1974.tb08565.x.
Abstract
1 We have compared the sensitivity of the prostaglandin synthetase systems derived from microsomal fractions of rabbit ocular tissues (anterior uvea, conjunctiva and retina) with other rabbit tissues such as the kidney medulla and spleen, to inhibition by indomethacin.2 Generation of prostaglandin-like activity by the microsomal fractions from added arachidonic acid varied with the tissue used. Highest activity was found in the kidney medulla, then in descending order, the conjunctiva, anterior uvea, spleen, retina and cornea.3 Indomethacin was most potent in the spleen (ID(50) 0.045 mug/ml) then in decreasing order in the kidney medulla, conjunctiva, anterior uvea and weakest in the retina, where the ID(50) for indomethacin was 50 mug/ml.4 The differential sensitivity to inhibition of the prostaglandin synthetase systems from different tissues is an important consideration in the development of new ocular anti-inflammatory agents.
摘要
我们已将源自兔眼组织（前葡萄膜、结膜和视网膜）微粒体部分的前列腺素合成酶系统与其他兔组织（如肾髓质和脾脏）对吲哚美辛抑制作用的敏感性进行了比较。
从添加的花生四烯酸中由微粒体部分产生的类前列腺素活性随所用组织而变化。在肾髓质中发现活性最高，然后依次为结膜、前葡萄膜、脾脏、视网膜和角膜。
吲哚美辛在脾脏中效力最强（半数抑制浓度为0.045微克/毫升），然后在肾髓质、结膜、前葡萄膜中效力依次降低，在视网膜中最弱，吲哚美辛在视网膜中的半数抑制浓度为50微克/毫升。
不同组织的前列腺素合成酶系统对抑制作用的差异敏感性是开发新型眼部抗炎药物时的一个重要考虑因素。
相似文献
1
Inhibition of the prostaglandin synthetase systems in ocular tissues by indomethacin.吲哚美辛对眼组织中前列腺素合成酶系统的抑制作用。
Br J Pharmacol. 1974 Feb;50(2):227-30. doi: 10.1111/j.1476-5381.1974.tb08565.x.
2
A comparison of the inhibitory activity of compounds on ocular prostaglandin biosynthesis.化合物对眼部前列腺素生物合成的抑制活性比较。
Invest Ophthalmol. 1974 Dec;13(12):967-72.
3
Prostaglandin synthetase systems of rabbit tissues and their inhibition by nonsteroidal anti-inflammatory drugs.兔组织的前列腺素合成酶系统及其被非甾体抗炎药的抑制作用。
J Pharmacol Exp Ther. 1976 Jan;196(1):226-30.
4
Biosynthesis of prostaglandins in rabbit renal cortex.前列腺素在兔肾皮质中的生物合成。
Res Commun Chem Pathol Pharmacol. 1976 Jan;13(1):115-23.
5
Antiinflammatory agents and inhibition of ocular prostaglandin synthetase.抗炎药与眼内前列腺素合成酶的抑制
Adv Prostaglandin Thromboxane Res. 1976;2:819-23.
6
Cyclooxygenase and lipoxygenase pathways in anterior uvea and conjunctiva.眼前葡萄膜和结膜中的环氧化酶和脂氧合酶途径。
Prog Clin Biol Res. 1989;312:39-52.
7
Comparative in vivo inhibitory effects of nonsteroidal anti-inflammatory agents on prostaglandin synthesis in rabbit ocular tissues.非甾体抗炎药对兔眼组织中前列腺素合成的体内比较抑制作用。
Arch Ophthalmol. 1985 Jan;103(1):103-6. doi: 10.1001/archopht.1985.01050010109031.
8
Properties of prostaglandin synthetase of rabbit kidney medulla.兔肾髓质前列腺素合成酶的特性
Eur J Biochem. 1976 May 1;64(2):527-34. doi: 10.1111/j.1432-1033.1976.tb10332.x.
9
Light emission during the action of prostaglandin synthetase.前列腺素合成酶作用过程中的发光现象。
Biochem Biophys Res Commun. 1974 Oct 23;60(4):1286-94. doi: 10.1016/0006-291x(74)90337-4.
10
The generation from arachidonic acid of rabbit aorta contracting substance (RCS) by a microsomal enzyme preparation which also generates prostaglandins.一种微粒体制剂可从花生四烯酸生成兔主动脉收缩物质（RCS），该制剂也能生成前列腺素。
Br J Pharmacol. 1972 Nov;46(3):449-57. doi: 10.1111/j.1476-5381.1972.tb08142.x.
引用本文的文献
1
The Effect of NSAID Pretreatment on Aqueous Humor Prostaglandin E Concentration in Eyes Undergoing Femtosecond Laser-Assisted Capsulotomy.非甾体抗炎药预处理对接受飞秒激光辅助白内障囊切开术患者眼房水前列腺素E浓度的影响
J Ophthalmol. 2018 Jul 10;2018:1891249. doi: 10.1155/2018/1891249. eCollection 2018.
2
[Not Available].[无可用内容]
Doc Ophthalmol. 1984 May;57(3):215-262. doi: 10.1007/BF00143085.
3
Levels of prostaglandin E2 and leukotriene B4 in tears of vernal conjunctivitis patients during a therapeutic trial with indomethacin.在使用消炎痛进行治疗试验期间，春季结膜炎患者泪液中前列腺素E2和白三烯B4的水平。
Doc Ophthalmol. 1994;85(3):247-57. doi: 10.1007/BF01664932.
4
Potential therapeutic applications of aspirin and other cyclo-oxygenase inhibitors.阿司匹林及其他环氧化酶抑制剂的潜在治疗应用。
Br J Clin Pharmacol. 1980 Oct;10 Suppl 2(Suppl 2):261S-278S. doi: 10.1111/j.1365-2125.1980.tb01809.x.
5
Indomethacin eyedrops and the postoperative irritation after extracapsular cataract extraction combined with intraocular lens implantation.吲哚美辛滴眼液与白内障囊外摘除联合人工晶状体植入术后的刺激反应
Doc Ophthalmol. 1983 Dec 15;56(1-2):165-70. doi: 10.1007/BF00154725.
6
The effect of YAG laser iridotomy on the blood aqueous barrier in the rabbit.YAG激光虹膜切开术对兔血-房水屏障的影响。
Graefes Arch Clin Exp Ophthalmol. 1984;221(4):179-81. doi: 10.1007/BF02134261.
7
Effect of indomethacin in preventing surgically induced miosis.吲哚美辛在预防手术引起的瞳孔缩小中的作用。
Br J Ophthalmol. 1983 Feb;67(2):94-6. doi: 10.1136/bjo.67.2.94.
8
Topical indomethacin effect on neovascularisation of the cornea and on prostaglandin E2 levels.局部用吲哚美辛对角膜新生血管形成及前列腺素E2水平的影响。
Br J Ophthalmol. 1984 Sep;68(9):656-9. doi: 10.1136/bjo.68.9.656.
9
The effect of topically applied prostaglandin inhibitors on the laser-induced disruption of the blood aqueous barrier.局部应用前列腺素抑制剂对激光诱导的血-房水屏障破坏的影响。
Doc Ophthalmol. 1985 Apr 30;59(3):269-75. doi: 10.1007/BF00159264.
10
Effects of topical indomethacin pretreatment on argon laser trabeculoplasty: a randomised, double-masked study on black South Africans.局部用吲哚美辛预处理对氩激光小梁成形术的影响：一项针对南非黑人的随机双盲研究。
Br J Ophthalmol. 1985 Sep;69(9):668-72. doi: 10.1136/bjo.69.9.668.
本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
A sensitive method for the assay of 5-hydroxytryptamine.一种测定5-羟色胺的灵敏方法。
Br J Pharmacol Chemother. 1957 Sep;12(3):344-9. doi: 10.1111/j.1476-5381.1957.tb00146.x.
3
The biosynthesis of prostaglandin in pig eye iris.猪眼虹膜中前列腺素的生物合成。
Biochim Biophys Acta. 1967 Apr 4;137(2):396-9. doi: 10.1016/0005-2760(67)90117-8.
4
A simple chemical procedure for distinguishing E from F prostaglandins, with application to tissue extracts.一种区分E型和F型前列腺素的简单化学方法及其在组织提取物中的应用。
Br J Pharmacol Chemother. 1968 May;33(1):162-70.
5
Increased intraocular pressure produced by prostaglandins E1 and E2 in the cat eye.前列腺素E1和E2在猫眼内产生的眼压升高。
Exp Eye Res. 1970 Jul;10(1):87-92. doi: 10.1016/s0014-4835(70)80014-8.
6
Indomethacin in the treatment of uveitis. A double-blind trial.吲哚美辛治疗葡萄膜炎。一项双盲试验。
Trans Ophthalmol Soc U K (1962). 1965;85:53-8.
7
Indomethacin and aspirin abolish prostaglandin release from the spleen.吲哚美辛和阿司匹林可抑制前列腺素从脾脏释放。
Nat New Biol. 1971 Jun 23;231(25):237-9. doi: 10.1038/newbio231237a0.
8
Aspirin selectively inhibits prostaglandin production in human platelets.阿司匹林可选择性抑制人体血小板中前列腺素的生成。
Nat New Biol. 1971 Jun 23;231(25):235-7. doi: 10.1038/newbio231235a0.
9
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.抑制前列腺素合成作为阿司匹林类药物的作用机制。
Nat New Biol. 1971 Jun 23;231(25):232-5. doi: 10.1038/newbio231232a0.
10
Further studies on the effect of prostaglandin on intraocular pressure in the rabbit.前列腺素对兔眼内压影响的进一步研究。
Exp Eye Res. 1971 Mar;11(2):170-7. doi: 10.1016/s0014-4835(71)80020-9.
Zotero 插件