Miossec P, Youinou P, Le Goff P, Moineau M P
Clin Rheumatol. 1982 Sep;1(3):185-9. doi: 10.1007/BF02042772.
Antikeratin antibodies (AKA) were found in 38 out of 96 patients with rheumatoid arthritis (RA); they appeared to be quite characteristic to this disease. There was a very low incidence of AKA positivity in the control groups, i.e., 1 out of 62 healthy subjects and 4 out of 158 other patients. With regard to the sensitivity of the test as a diagnostic tool, AKA was found to be weaker than the rheumatoid factor (RF) and the antiperinuclear factor (APF), whereas the specificity was much better than APF and RF. A clear correlation was shown between the titres of AKA and APF (p less than 0.001) and also between AKA levels and inflammation (p less than 0.02).
在96例类风湿关节炎（RA）患者中，有38例检测出抗角蛋白抗体（AKA）；它们似乎是这种疾病的相当典型的特征。在对照组中，AKA阳性的发生率非常低，即62名健康受试者中有1例，158名其他患者中有4例。就该检测作为诊断工具的敏感性而言，发现AKA比类风湿因子（RF）和抗核周因子（APF）弱，而特异性比APF和RF好得多。AKA滴度与APF之间（p<0.001）以及AKA水平与炎症之间（p<0.02）均显示出明显的相关性。
