Scott D L, Delamere J P, Jones L J, Walton K W
Ann Rheum Dis. 1981 Jun;40(3):267-71. doi: 10.1136/ard.40.3.267.
Antikeratin antibodies reacting in a laminar distribution with keratinised rat oesophagus were found in the sera of a proportion of patients with rheumatoid arthritis but not in healthy controls. In rheumatoid arthritis (RA) the proportion of sera exhibiting this reactivity varied with the site tested in the rat's upper alimentary tract. There were 36.4% of 99 patients with RA who gave positive reactivity to the middle third of the rat oesophagus. This antikeratin reactivity was related to the occurrence of other antitissue antibodies (to reticulin, gastric parietal cells, smooth muscle, mitochondria, or nuclear components) in the same patients with rheumatoid arthritis. It was not related to the duration of early morning stiffness, the Ritchie index, the erythrocyte sedimentation rate, certain acute phase proteins (haptoglobin and C-reactive protein) nor to the levels of haemoglobin or immunoglobulins. Antikeratin antibodies were not specific for rheumatoid arthritis and also occurred in 50% of 16 patients with progressive systemic sclerosis.
在部分类风湿关节炎患者血清中发现了抗角蛋白抗体，这些抗体与角质化的大鼠食管呈层状分布反应，但在健康对照者血清中未发现。在类风湿关节炎（RA）中，表现出这种反应性的血清比例因大鼠上消化道测试部位而异。99例RA患者中有36.4%对大鼠食管中三分之一段呈阳性反应。这种抗角蛋白反应性与类风湿关节炎患者体内其他抗组织抗体（抗网状纤维、胃壁细胞、平滑肌、线粒体或核成分抗体）的出现有关。它与晨僵持续时间、里奇指数、红细胞沉降率、某些急性期蛋白（触珠蛋白和C反应蛋白）无关，也与血红蛋白或免疫球蛋白水平无关。抗角蛋白抗体并非类风湿关节炎所特有，在16例进行性系统性硬化症患者中，也有50%出现该抗体。
