Aho K, von Essen R, Kurki P, Palosuo T, Heliövaara M
National Public Health Institute, Helsinki, Finland.
J Rheumatol. 1993 Aug;20(8):1278-81.
Antikeratin antibody (AKA) and antiperinuclear factor (APF) are antibodies characteristic for rheumatoid arthritis (RA). Our purpose was to obtain information on the occurrence of APF before the onset of clinical disease and on the occurrence of AKA and APF in cases with false-positive rheumatoid factor (RF) reactions.
AKA and APF were measured with indirect immunofluorescence technique using rat esophagus and buccal mucosa cells, respectively, as antigen source.
Five of 30 preillness specimens from subjects who later developed seropositive RA were positive for AKA and APF, 3 sera were positive for only AKA and 3 for only APF. All the eleven sera positive for AKA or APF were RF positive. Both AKA and APF were detected in 6 of 70 sera from RF positive subjects who did not develop RA within a 10-year followup, 3 sera were positive for only AKA and 3 for only APF.
AKA and APF appear to be linked markers of an immunological process which, in RF positive subjects, predicts the development of clinical arthritis. However, disease manifestations develop in only a proportion of cases.
抗角蛋白抗体（AKA）和抗核周因子（APF）是类风湿关节炎（RA）的特征性抗体。我们的目的是获取临床疾病发作前APF的出现情况以及类风湿因子（RF）反应假阳性病例中AKA和APF的出现情况的信息。
分别以大鼠食管和颊黏膜细胞为抗原来源，采用间接免疫荧光技术检测AKA和APF。
在后来发展为血清阳性RA的受试者的30份发病前标本中，5份AKA和APF呈阳性，3份血清仅AKA呈阳性，3份仅APF呈阳性。所有11份AKA或APF呈阳性的血清RF均呈阳性。在70份RF阳性且在10年随访期内未发展为RA的受试者血清中，6份同时检测到AKA和APF，3份血清仅AKA呈阳性，3份仅APF呈阳性。
AKA和APF似乎是一种免疫过程的相关标志物，在RF阳性受试者中，可预测临床关节炎的发展。然而，只有一部分病例会出现疾病表现。
