β-咔啉-3-羧酸乙酯（一种苯二氮䓬受体拮抗剂）对猫的催眠作用。
Hypnotic action of ethyl beta-carboline-3-carboxylate, a benzodiazepine receptor antagonist, in cats.
作者信息
Kaijima M, Da Costa-Rochette L, Dodd R H, Rossier J, Naquet R
出版信息
Electroencephalogr Clin Neurophysiol. 1984 Sep;58(3):277-81. doi: 10.1016/0013-4694(84)90113-5.
The present study demonstrates that ethyl beta-carboline-3-carboxylate (beta-CCE), a benzodiazepine receptor antagonist, has hypnotic and sedative actions in cats. Moreover, at a dose that does not by itself affect sleep, beta-CCE reverses the action of diazepam on sleep organization. The hypnotic effect of subcutaneous administration of beta-CCE (5 mg/kg) lasts for 3-4 h. During this period, deep slow wave sleep (deep non-REM sleep) and paradoxical sleep (REM sleep) significantly increase, while wakefulness markedly decreases. These results, which are quite opposite to the effects of benzodiazepines on sleep organization in cats, support the notion that beta-CCE also acts as a benzodiazepine antagonist of sleep organization.
本研究表明，β-咔啉-3-羧酸乙酯（β-CCE）作为一种苯二氮䓬受体拮抗剂，对猫具有催眠和镇静作用。此外，在其本身不影响睡眠的剂量下，β-CCE可逆转地西泮对睡眠结构的作用。皮下注射β-CCE（5mg/kg）的催眠作用持续3 - 4小时。在此期间，深度慢波睡眠（深度非快速眼动睡眠）和异相睡眠（快速眼动睡眠）显著增加，而清醒状态明显减少。这些结果与苯二氮䓬类药物对猫睡眠结构的影响完全相反，支持了β-CCE也作为睡眠结构的苯二氮䓬拮抗剂起作用的观点。
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