Friedlander M L, Atkinson K, Coppleson J V, Elliot P, Green D, Houghton R, Solomon H J, Russell P, Tattersall M H
Gynecol Oncol. 1984 Sep;19(1):1-7. doi: 10.1016/0090-8258(84)90150-1.
Chemotherapy has been traditionally reserved as a last-time treatment for cervical cancer patients and in this setting long-term remissions are unusual. Platinum-based combination chemotherapy has been associated with high tumor response rates in patients with advanced and metastatic cervical tumors and past experience encouraged evaluation of chemotherapy as a first-line treatment in patients with locally advanced tumors where there is a high likelihood of relapse with local treatment. Thirty patients were treated initially with three courses of cis-platinum, vinblastine, and bleomycin with an overall response rate of 67%, and then had either radiotherapy or surgical resection. The initial results have been encouraging and the integration of chemotherapy into the management of locally advanced cervical cancer warrants further investigation.
传统上，化疗一直是宫颈癌患者的最后一种治疗手段，在这种情况下，长期缓解并不常见。铂类联合化疗已被证实与晚期和转移性宫颈肿瘤患者的高肿瘤缓解率相关，以往的经验促使人们将化疗评估为局部晚期肿瘤患者的一线治疗方法，因为这些患者接受局部治疗后复发可能性很高。30例患者最初接受了三个疗程的顺铂、长春碱和博来霉素治疗，总缓解率为67%，随后接受了放疗或手术切除。初步结果令人鼓舞，将化疗纳入局部晚期宫颈癌的治疗值得进一步研究。
