Combination chemotherapy with cisplatin, vinblastine, and bleomycin for endodermal sinus tumor of the ovary.

Four consecutive patients with endodermal sinus tumor of the ovary were treated following surgery with intensive combination chemotherapy consisting of cisplatin, vinblastine, and bleomycin. All four of these patients remain continuously free of recurrent disease from 22 to 43 months following their original diagnosis. Two patients developed severe pulmonary toxicity related to the administration of bleomycin. Both of these patients also experienced Raynaud's phenomenon. The two patients whose initial surgery consisted of unilateral salpingo-oophorectomy have regular, spontaneous menstrual cycles, and one of them has become pregnant twice following the completion of chemotherapy.