顺铂、长春碱和博来霉素治疗卵巢卵黄囊（内胚窦）瘤

Cisplatin, vinblastine, and bleomycin therapy of yolk sac (endodermal sinus) tumor of the ovary.

作者信息

Sawada M, Okudaira Y, Matsui Y, Nishiura H, Iwasaki T, Kasamatsu H

出版信息

Gynecol Oncol. 1985 Feb;20(2):162-9. doi: 10.1016/0090-8258(85)90137-4.

Abstract

Five patients with yolk sac (endodermal sinus) tumor of the ovary were treated with cisplatin, vinblastine, and bleomycin combination therapy (PVB). Four of five achieved a complete remission and remain free from disease 24 to 53 months from start of PVB therapy. One patient did not respond well to PVB and died 11 months after start of PVB therapy. One patient who was treated with PVB after unilateral salpingo-oophorectomy has delivered a normal term infant. Serum alpha-fetoprotein levels were monitored in all patients during and after therapy. Serum alpha-fetoprotein was correlated with clinical course.

摘要

5例卵巢卵黄囊（内胚窦）瘤患者接受了顺铂、长春碱和博来霉素联合治疗（PVB）。5例中有4例达到完全缓解，自PVB治疗开始后24至53个月无疾病复发。1例患者对PVB反应不佳，在PVB治疗开始后11个月死亡。1例在单侧输卵管卵巢切除术后接受PVB治疗的患者足月分娩了一名正常婴儿。在所有患者治疗期间及治疗后监测血清甲胎蛋白水平。血清甲胎蛋白与临床病程相关。