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[储存期间血液及红细胞浓缩物的氧运输功能及其对输血的重要性]

[The oxygen transport function of the blood and of the erythrocyte concentrate during storage and its importance for blood transfusion].

作者信息

Terechow N, Petrow M, Beresowsky B

出版信息

Folia Haematol Int Mag Klin Morphol Blutforsch. 1984;111(3):360-9.

PMID:6205964
Abstract

The property of oxygen transport function was investigated in blood which had been stored in solutions of "glugizir" and "zitroglucophosphate" and in erythrocyte concentrates gained from it on the noughth, 7th, 14th und 21st day of storage at -4 +/- 2 degrees C. The parameters of the oxygen binding function (oxygen content of erythrocytes, half time of haemoglobin saturation with oxygen, concentration of organic phosphate [2.3 diphosphoglycerate and adenosine triphosphate] and those of inorganic phosphorus were determined in erythrocytes. During storage for more than 21 days no significant differences could be detected in the property of oxygen transfer between erythrocytes of stored blood and erythrocyte concentrate, with the values for storing in zitroglucophosphate being somewhat higher. Problems of applying all components of donor blood efficiently are discussed. In performing an adequate haemotherapy with blood components the importance of a functional condition of erythrocytes and oxygen balance in the organism of the receiver should be considered. The necessity of transfusing erythrocyte concentrate in the therapy of anaemias of different genesis is emphasized and the differences in applying concentrates in different plasma solutions are referred to. By transfusing concentrates the effectiveness of hemotherapy are elevated and the rate of complications and side-effects of whole blood are diminished.

摘要

在-4±2℃条件下,对储存于“葡萄糖酸锌”和“磷酸葡萄糖酸锌”溶液中的血液及其在储存第0天、第7天、第14天和第21天获得的红细胞浓缩物的氧运输功能特性进行了研究。测定了红细胞中氧结合功能的参数(红细胞中的氧含量、血红蛋白氧饱和度的半衰期、有机磷酸盐[2,3-二磷酸甘油酸和三磷酸腺苷]的浓度以及无机磷的浓度)。在储存超过21天时,储存血液的红细胞与红细胞浓缩物之间的氧转运特性未检测到显著差异,在磷酸葡萄糖酸锌中储存的值略高。讨论了有效应用献血者血液所有成分的问题。在使用血液成分进行适当的血液治疗时,应考虑红细胞功能状态和受者机体氧平衡的重要性。强调了在不同病因贫血治疗中输注红细胞浓缩物的必要性,并提及了在不同血浆溶液中应用浓缩物的差异。通过输注浓缩物,提高了血液治疗的有效性,降低了全血的并发症和副作用发生率。

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