Quirion R, Pilapil C
Neuropeptides. 1984 Jun;4(4):325-9. doi: 10.1016/0143-4179(84)90007-6.
The relative potency of substance P, substance K and neuromedin K on [3H]substance P binding has been compared in rat brain membrane preparations. Substance K and neuromedin K, two newly isolated substance P-related mammalian peptides, are very weak competitors for [3H]substance P binding sites. It suggests that these two neuropeptides are not acting on the same receptor type as substance P. Moreover, previous substance P receptor classifications are unlikely to be applicable to brain tachykinin receptor sub-types.
在大鼠脑膜制剂中比较了P物质、K物质和神经介素K对[3H]P物质结合的相对效力。K物质和神经介素K是两种新分离出的与P物质相关的哺乳动物肽，它们对[3H]P物质结合位点的竞争作用非常弱。这表明这两种神经肽作用的受体类型与P物质不同。此外，先前的P物质受体分类不太可能适用于脑速激肽受体亚型。
