Saito H, Asakawa H, Otawa H, Nemoto K, Saito H
Gan To Kagaku Ryoho. 1984 Sep;11(9):1789-93.
Efficacy, survival rats and adverse effects of the combined therapy of irradiation with intravaginal bleomycin suppositories were analyzed and discussed in 49 patients with uterine cervical cancer. The results were as follows: Histological examination of biopsy specimens from the uterine cervix taken just after the completion of this treatment showed favorable control over the primary lesions. However, the efficacy of the bleomycin suppositories was too mild to form a basis for treatment without intracavitary irradiation. Because of the low concentration of bleomycin in serum after suppository administration, it is thought that bleomycin would have little effect on distant metastases. Survival rates in stage III patients were 83% at 12 months, 77% at 24 months and 70% at 36 months. These were superior to those for irradiation alone. The major adverse effect of bleomycin suppositories was fever, reduction of the bleomycin dose in each suppository but controlled this to some extent Lung fibrosis or severe damage to the liver, kidney and bone marrow were not found.
对49例宫颈癌患者分析讨论了阴道内博来霉素栓剂联合放疗的疗效、大鼠生存率及不良反应。结果如下：治疗结束后立即取自子宫颈的活检标本组织学检查显示对原发灶控制良好。然而，博来霉素栓剂的疗效过于轻微，无法作为无腔内放疗的治疗依据。由于栓剂给药后血清中博来霉素浓度较低，认为博来霉素对远处转移影响较小。III期患者12个月生存率为83%，24个月生存率为77%，36个月生存率为70%。这些均优于单纯放疗。博来霉素栓剂的主要不良反应是发热，减少每个栓剂中的博来霉素剂量可在一定程度上控制发热。未发现肺纤维化或肝、肾及骨髓的严重损害。
