Yamanashi S, Abe T, Mochizuki S, Murakami Y, Iida N
Dept. of Radiology, Jikei University School of Medicine.
Gan To Kagaku Ryoho. 1990 Feb;17(2):245-51.
By means of re-irradiation using pepleomycin suppository in uterine cavity, we attained local control for one patient who had local recurrence in uterine cavity and suffered from uterine fluor in which viable cancer cells were confirmed. We were enlightened by this therapeutic experience, so we attempted combination therapy using pepleomycin suppositories to supplement intra-cavitary irradiation, for the 11 selected patients who were suffering from uterine fluor. We investigated the treatment results in 7 patients of stage III out of 11 patients (of all stages), in comparison with 13 patients of stage III who were treated by irradiation alone. Consequently, these treatment results were approximately equivalent, and the incidence of sigmoid complications could be decreased. Side effects which were followed by the combination therapy were not serious, and so we believe that pepleomycin suppository is a simple method and valuable to supplement radiation therapy of uterine cervical cancer.
通过使用平阳霉素栓剂对宫腔进行再照射，我们对1例宫腔局部复发且患有子宫糜烂并证实有存活癌细胞的患者实现了局部控制。我们从这一治疗经验中得到启发，因此尝试对11例患有子宫糜烂的选定患者使用平阳霉素栓剂进行联合治疗以补充腔内照射。我们对11例患者（各期均有）中的7例III期患者的治疗结果进行了调查，并与13例仅接受放疗的III期患者进行了比较。结果，这些治疗结果大致相当，且乙状结肠并发症的发生率可以降低。联合治疗后的副作用并不严重，所以我们认为平阳霉素栓剂是一种简单的方法，对补充子宫颈癌放射治疗很有价值。
