Jankowska R, Szalaty H, Małolepszy J
Arch Immunol Ther Exp (Warsz). 1984;32(1):9-17.
The present paper discusses the correlation between NDV-induced interferon production and the degree of histamine release from mouse mastocytes. The injection of mice with Newcastle virus was observed to substantially increase the percentage of released histamine and the degree of mastocytes degranulation. A clear-cut correlation was observed between virus-induced interferon titer and the degree of histamine release both in nonsensitized (control) as well as in sensitized mice. In sensitized animals, however, interferon titer, the percentage of histamine release and degree of mastocytes degranulation was higher. Polyvalent bacterial vaccine was shown to exert the inhibitory effect on the production of interferon induced both in sensitized and nonsensitized mice, however, its influence on the amount of histamine released was not confirmed.
本文讨论了新城疫病毒（NDV）诱导的干扰素产生与小鼠肥大细胞组胺释放程度之间的相关性。观察到给小鼠注射新城疫病毒会显著增加组胺释放百分比和肥大细胞脱颗粒程度。在未致敏（对照）小鼠和致敏小鼠中，均观察到病毒诱导的干扰素滴度与组胺释放程度之间存在明显的相关性。然而，在致敏动物中，干扰素滴度、组胺释放百分比和肥大细胞脱颗粒程度更高。已表明多价细菌疫苗对致敏和未致敏小鼠诱导产生的干扰素均有抑制作用，但其对组胺释放量的影响尚未得到证实。
