van Cangh P J, Ferrant A, Ninane J, Deckers C
Eur Urol. 1984;10(4):266-71. doi: 10.1159/000463805.
Radioimmunodetection with an 131I anti-alpha-fetoprotein (alpha FP) has been performed in 5 patients with germ cell tumors. In 3 of them, 5 of 6 recognized or suspected tumor sites could be demonstrated. In 1 of these patients, a clinically non-apparent primary tumor was detected by this method. The 2 other patients had received intensive chemotherapy and had a persistent elevation of serum alpha FP, although usual paraclinical examinations were normal. In these patients, the labelled antibody scan did not show any abnormality. These results suggest that radioimmunodetection can be useful in patients with nonseminomatous gonadal and extragonadal tumors at the time of presentation. Usefulness of radioimmunodetection in the follow-up of these patients remains to be determined. Even in our limited series, radioimmunodetection was of no help on localizing the sites of alpha FP secretion in treated patients in whom other methods had also failed to recognize the site of abnormal alpha FP synthesis.
对5例生殖细胞肿瘤患者进行了¹³¹I抗甲胎蛋白（αFP）放射免疫检测。其中3例患者，6个已确认或疑似肿瘤部位中的5个能够被检测出来。在其中1例患者中，通过该方法检测到了临床上不明显的原发性肿瘤。另外2例患者接受了强化化疗，尽管常规临床检查正常，但血清αFP持续升高。在这些患者中，标记抗体扫描未显示任何异常。这些结果表明，放射免疫检测在非精原细胞瘤性性腺和性腺外肿瘤患者初诊时可能有用。放射免疫检测在这些患者随访中的有用性仍有待确定。即使在我们有限的病例系列中，对于那些其他方法也未能识别异常αFP合成部位的接受治疗的患者，放射免疫检测在定位αFP分泌部位方面也没有帮助。
