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通过一种新型偶联方法将丝裂霉素C与抗甲胎蛋白抗体偶联，增强其抗肿瘤活性。

Enhanced antitumor activity of mitomycin C conjugated with anti-alpha-fetoprotein antibody by a novel method of conjugation.

作者信息

Kato Y, Tsukada Y, Hara T, Hirai H

出版信息

J Appl Biochem. 1983 Aug-Oct;5(4-5):313-9.

PMID:6207159
Abstract

Mitomycin C (MMC) was conjugated to horse anti-rat alpha-fetoprotein (AFP) antibody at the N-1a position through a glutaric acid-derived spacer arm. In vitro studies showed that MMC was spontaneously and slowly released from the conjugate. The conjugate caused a greater inhibition of both the in vitro and in vivo tumor growth of the AFP-producing rat hepatoma AH66 than did a mixture of anti-rat AFP antibody and MMC or a similar conjugate of MMC with normal horse immunoglobulin.

摘要

丝裂霉素C（MMC）通过戊二酸衍生的间隔臂在N-1a位置与马抗大鼠甲胎蛋白（AFP）抗体偶联。体外研究表明，MMC从偶联物中自发且缓慢释放。与抗大鼠AFP抗体和MMC的混合物或MMC与正常马免疫球蛋白的类似偶联物相比，该偶联物对产生AFP的大鼠肝癌AH66的体外和体内肿瘤生长均具有更强的抑制作用。

相似文献

1
Enhanced antitumor activity of mitomycin C conjugated with anti-alpha-fetoprotein antibody by a novel method of conjugation.通过一种新型偶联方法将丝裂霉素C与抗甲胎蛋白抗体偶联，增强其抗肿瘤活性。
J Appl Biochem. 1983 Aug-Oct;5(4-5):313-9.
2
[Chemical modification of anti-cancer drugs to increase their affinity to tumor antigens].[抗癌药物的化学修饰以增强其对肿瘤抗原的亲和力]
Gan To Kagaku Ryoho. 1985 Mar;12(3 Pt 2):741-50.
3
Conjugates of mitomycin with anti-alpha-fetoprotein antibody: antitumor effect against alpha-fetoprotein-producing human gastric carcinoma implanted in nude mice.丝裂霉素与抗甲胎蛋白抗体的偶联物：对裸鼠体内移植的产甲胎蛋白人胃癌的抗肿瘤作用
NCI Monogr. 1987(3):101-5.
4
Conjugates of mitomycin C with the immunoglobulin M monomer fragment of a monoclonal anti-MM46 immunoglobulin M antibody with or without serum albumin as intermediary.丝裂霉素C与单克隆抗-MM46免疫球蛋白M抗体的免疫球蛋白M单体片段的缀合物，有无血清白蛋白作为中间体。
J Appl Biochem. 1984 Oct-Dec;6(5-6):297-307.
5
[Anti-tumor activity of an anti-human alpha-fetoprotein antibody-human serum albumin-mitomycin C conjugate against human yolk sac tumor maintained in vitro and in nude mice in vivo].抗人甲胎蛋白抗体-人血清白蛋白-丝裂霉素C偶联物对体外培养及裸鼠体内人卵黄囊瘤的抗肿瘤活性
Gan To Kagaku Ryoho. 1986 Mar;13(3 Pt 1):563-9.
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An anti-alpha-fetoprotein antibody-daunorubicin conjugate with a novel poly-L-glutamic acid derivative as intermediate drug carrier.一种以新型聚-L-谷氨酸衍生物作为中间药物载体的抗甲胎蛋白抗体-柔红霉素偶联物。
J Natl Cancer Inst. 1984 Sep;73(3):721-9.
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[Importance of the conjugated antibody for the induction of selective effect of adriamycin conjugated with anti AFP monoclonal antibody and entrapped in liposomes against AFP producing tumors].[共轭抗体对诱导阿霉素与抗甲胎蛋白单克隆抗体共轭并包裹于脂质体中以对抗产生甲胎蛋白肿瘤的选择性作用的重要性]
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Selective cytotoxicity against human tumor cells by an anti-gastric cancer monoclonal antibody-mitomycin C conjugate.
Zhongguo Yao Li Xue Bao. 1990 Jul;11(4):367-70.
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[Specific targeting of mitomycin C to tumors with the use of anti-gastric cancer monoclonal antibody].
Zhonghua Yi Xue Za Zhi. 1990 Jul;70(7):363-6, 26.
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Specific targeting of mitomycin C to tumors by anti-gastric cancer monoclonal antibody.抗胃癌单克隆抗体介导丝裂霉素C对肿瘤的特异性靶向作用。
Chin Med J (Engl). 1991 May;104(5):358-62.

引用本文的文献

1
Markers for internal neoplasia in the horse.马的内部肿瘤标志物。
Vet Med Sci. 2023 Jan;9(1):132-143. doi: 10.1002/vms3.1042. Epub 2022 Dec 10.
2
Immunotoxins and anticancer drug conjugate assemblies: the role of the linkage between components.免疫毒素和抗癌药物偶联物组装：各组分间连接体的作用。
Toxins (Basel). 2011 Jul;3(7):848-83. doi: 10.3390/toxins3070848. Epub 2011 Jul 14.
3
Chemotherapeutic efficacy of the protein-doxorubicin conjugates on multidrug resistant rat hepatoma cell line in vitro.蛋白质-阿霉素偶联物对多药耐药大鼠肝癌细胞系的体外化疗疗效
Br J Cancer. 1993 Feb;67(2):274-8. doi: 10.1038/bjc.1993.52.
4
Selective in vitro and in vivo growth inhibition against human yolk sac tumor cell lines by purified antibody against human alpha-fetoprotein conjugated with mitomycin C via human serum albumin.通过人血清白蛋白与丝裂霉素C偶联的抗人甲胎蛋白纯化抗体对人卵黄囊瘤细胞系进行体外和体内选择性生长抑制。
Cancer Immunol Immunother. 1986;23(2):81-6. doi: 10.1007/BF00199811.
5
Suppression of human alpha-foetoprotein-producing hepatocellular carcinoma growth in nude mice by an anti alpha-foetoprotein antibody-daunorubicin conjugate with a poly-L-glutamic acid derivative as intermediate drug carrier.以聚-L-谷氨酸衍生物作为中间药物载体的抗甲胎蛋白抗体-柔红霉素缀合物对裸鼠人甲胎蛋白产生性肝细胞癌生长的抑制作用
Br J Cancer. 1985 Jul;52(1):111-6. doi: 10.1038/bjc.1985.157.