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依赖DNA的DNA聚合酶：病毒白血病发生过程中对细胞增殖可能产生的限制影响。

DNA-dependent-DNA-polymerase: possible limiting influence on cell reproduction during viral leukemogenesis.

作者信息

Okunewick J P, Braunschweiger P G

出版信息

Experientia. 1978 Jan 15;34(1):108-9. doi: 10.1007/BF01921932.

DOI:10.1007/BF01921932
PMID:620718
Abstract

Evidence is presented that during viral leukemogenesis spleen cell nuclei show an increase in labelling index and mean grain count, that is not accompanied by any changes in the nuclear level of DNA-polymerase-alpha. It is suggested that polymerase production remains under the control of the normal cell mechanisms and the virus may affect cell proliferation by altering the primer-template levels.

摘要

有证据表明，在病毒性白血病发生过程中，脾细胞核的标记指数和平均颗粒计数增加，而DNA聚合酶α的核水平没有任何变化。有人提出，聚合酶的产生仍受正常细胞机制的控制，病毒可能通过改变引物-模板水平来影响细胞增殖。

相似文献

1
DNA-dependent-DNA-polymerase: possible limiting influence on cell reproduction during viral leukemogenesis.依赖DNA的DNA聚合酶：病毒白血病发生过程中对细胞增殖可能产生的限制影响。
Experientia. 1978 Jan 15;34(1):108-9. doi: 10.1007/BF01921932.
2
[Activity of DNA-dependent RNA polymerases A and B in spleen nuclei of mice infected with Rauscher leukemia virus].[劳舍尔白血病病毒感染小鼠脾脏细胞核中DNA依赖性RNA聚合酶A和B的活性]
Vopr Virusol. 1976 Jan-Feb(1):57-62.
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Organ distribution of reverse transcriptase and cellular DNA polymerases in Friend virus-infected mice: analysis by phosphocellulose column chromatography.逆转录酶和细胞DNA聚合酶在感染Friend病毒小鼠中的器官分布：通过磷酸纤维素柱色谱法进行分析
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Preparation of RNA-directed DNA polymerase from spleens of Balb-c mice infected with Rauscher leukemia virus.从感染劳斯氏白血病病毒的Balb-c小鼠脾脏中制备RNA指导的DNA聚合酶。
Biochem Biophys Res Commun. 1972 Apr 28;47(2):505-11. doi: 10.1016/0006-291x(72)90743-7.
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Virus-specific reverse transcriptase in acute leukaemia.急性白血病中的病毒特异性逆转录酶
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Purification of RNA-directed DNA polymerase from spleens of BALB/C mice infected with Rauscher leukemia virus [proceedings].从感染劳斯氏白血病病毒的BALB/C小鼠脾脏中纯化RNA指导的DNA聚合酶[会议论文集]
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Role of cellular RNA polymerases in virus-induced leukemogenesis.
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Deoxyribonucleic acid-dependent ribonucleic acid polymerases from spleen of uninfected and Rauscher murine leukemia virus-infected NIH Swiss mice.?来自未感染和劳氏鼠白血病病毒感染的NIH瑞士小鼠脾脏的脱氧核糖核酸依赖性核糖核酸聚合酶。
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[Effect of methotrexate on the activity of DNA-dependent RNA polymerases (A and B) in the spleen of mice infected with Rauscher leukemia virus and on the development of virus-induced leukemia].[甲氨蝶呤对感染劳斯氏白血病病毒的小鼠脾脏中DNA依赖性RNA聚合酶（A和B）活性及病毒诱导白血病发生的影响]
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RNA polymerase activity following infection with murine leukemia virus.
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本文引用的文献

1
Autoradiographic analysis of cell proliferation in spontaneous breast cancer of C3H mouse. III. The growth fraction.C3H小鼠自发性乳腺癌细胞增殖的放射自显影分析。III. 生长分数。
J Natl Cancer Inst. 1962 May;28:1015-29.
2
GROWTH CURVE OF A MURINE LEUKEMIA VIRUS IN MICE.小鼠白血病病毒在小鼠体内的生长曲线
J Natl Cancer Inst. 1964 Feb;32:269-75.
3
Sulfhydryl groups and estradiol-receptor interaction.巯基与雌二醇受体的相互作用
Science. 1967 Oct 20;158(3799):385-7. doi: 10.1126/science.158.3799.385.
4
Cycling characteristics of human lymphocytes in vitro.人淋巴细胞体外循环特征
Blood. 1974 Jul;44(1):99-107.
5
Growth rate and 59 Fe uptake in the progeny of Rauscher leukemia virus-infected splenic colony forming units following transplantation.移植后劳氏肉瘤病毒感染的脾集落形成单位子代的生长速率及59铁摄取量
J Lab Clin Med. 1973 Apr;81(4):489-96.
6
The presence of unique DNA sequences after viral induction of leukemia in mice. (RNA tumor virus-nucleic acid hybridization-insertion of viral DNA).小鼠白血病病毒诱导后独特DNA序列的存在。（RNA肿瘤病毒-核酸杂交-病毒DNA的插入）
Proc Natl Acad Sci U S A. 1974 May;71(5):1705-9. doi: 10.1073/pnas.71.5.1705.
7
Colony forming unit suicide in normal and Rauscher leukemic mice given tritiated thymidine in vivo.在体内给予氚标记胸腺嘧啶核苷的正常和劳舍尔白血病小鼠中集落形成单位自杀
Exp Hematol. 1974;2(1):9-15.
8
Antiserum inactivation of hematopoietic colony forming stem cells from mice with Rauscher leukemia.劳舍尔白血病小鼠造血集落形成干细胞的抗血清灭活作用
Experientia. 1974 Dec 15;30(12):1470-1. doi: 10.1007/BF01919701.
9
[Hemopoietic stem cells in murine viurs-induced leukemia. I. Spleen colony assays in CBA mice after Rauscher virus infection (author's transl)].[小鼠病毒诱导白血病中的造血干细胞。I. 劳舍尔病毒感染后CBA小鼠的脾集落测定（作者译）]
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1973;79(2):123-34. doi: 10.1007/BF00284388.
10
The haematopoietic stem cell in Rauscher virus-induced erythroblastosis of BALB/c mice.劳氏肉瘤病毒诱导的BALB/c小鼠成红细胞增多症中的造血干细胞。
Eur J Cancer (1965). 1974 Dec;10(12):827-33. doi: 10.1016/0014-2964(74)90141-8.