Korttila K, Gröhn P, Gordin A, Sundberg S, Salo H, Nissinen E, Mattila M A
J Clin Pharmacol. 1984 Jul;24(7):273-82. doi: 10.1002/j.1552-4604.1984.tb01833.x.
Six healthy male subjects were given in a crossover fashion medium molecular weight (HES 125) and low molecular weight (HES 40) hydroxyethyl starch, dextran, and balanced salt solution by intravenous infusion. The plasma volumes were determined using labeled albumin and plasma protein measurements. Three properties of factor VIII protein complex and indices of blood coagulation and hemostasis were measured before and after the infusions. Both the salt solution and HES 40 increased plasma volume, but their effect wore off within 3 hours. Dextran and HES 125 increased plasma volume significantly (P less than 0.001) more than the salt solution did, and the expansion was maintained for 24 hours. Plasma volume increases (dextran and HES 125) were associated with high nonglucose carbohydrate levels in plasma and low levels in urine. No or slight increases in plasma volumes (HES 40), on the other hand, were associated with low and high carbohydrate levels in plasma and urine, respectively. Serum alpha-amylase activity increased significantly after both HES preparations as compared to salt solution. Dextran and HES 125 decreased all the three values of factor VIII, these decreases being maximal 3 to 6 hours after administration and highest (about 25 per cent) for F VIII R:Ag and F VIII R:cof. It is concluded that HES 125 and dextran are equally effective plasma expanders.
六名健康男性受试者采用交叉方式，通过静脉输注给予中分子量（HES 125）和低分子量（HES 40）羟乙基淀粉、右旋糖酐和平衡盐溶液。使用标记白蛋白和血浆蛋白测量法测定血浆容量。在输注前后测量了凝血因子VIII蛋白复合物的三个特性以及凝血和止血指标。盐溶液和HES 40均增加了血浆容量，但它们的作用在3小时内消失。右旋糖酐和HES 125使血浆容量显著增加（P小于0.001），且扩容作用维持24小时。血浆容量增加（右旋糖酐和HES 125）与血浆中非葡萄糖碳水化合物水平高和尿液中水平低有关。另一方面，血浆容量无增加或轻微增加（HES 40）分别与血浆和尿液中碳水化合物水平低和高有关。与盐溶液相比，两种HES制剂给药后血清α淀粉酶活性均显著增加。右旋糖酐和HES 125降低了凝血因子VIII的所有三个值，这些降低在给药后3至6小时最大，F VIII R:Ag和F VIII R:cof降低最为明显（约25%）。结论是HES 125和右旋糖酐是同样有效的血浆扩容剂。
