血浆扩容剂对血液凝固性影响的实验研究
An experimental study on the effect of plasma expanders on blood coagulability.
作者信息
Narita T, Matsumoto I, Kumazawa T, Ikezono E
出版信息
Bull Tokyo Med Dent Univ. 1979 Mar;26(1):25-32.
The effect of various plasma expanders on blood coagulation was studied using the thromboelastography (TEG). Solutions of 5, 10, 20, and 50% concentration of each expander (6% low molecular weight hydroxyethyl-starch (6% Hespander), 3% dextran-40, 6% high molecular weight hydroxyethyl-starch (6 HES), and 6% dextran-70) or solvent (lactated Ringer solution and normal saline) in blood were prepared and their coagulability was examined by TEG. In the low molecular weight plasma expanders (6% Hespander and 3% dextran-40), in general, the coagulability decreased when the concentration was increased. In the high molecular weight plasma expanders (6 HES and 6% dextran-70), the coagulability increased slightly at low and high concentrations and the coagulability was reduced. As a conclusion, at clinically used concentrations of less than 20% in blood, changes in the TEG of the plasma expanders are minimum and have no clinical significance.
使用血栓弹力图（TEG）研究了各种血浆扩容剂对血液凝固的影响。制备了每种扩容剂（6%低分子羟乙基淀粉（6%贺斯）、3%右旋糖酐-40、6%高分子羟乙基淀粉（6%HES）和6%右旋糖酐-70）或溶剂（乳酸林格溶液和生理盐水）在血液中的5%、10%、20%和50%浓度的溶液，并通过TEG检测其凝固性。在低分子血浆扩容剂（6%贺斯和3%右旋糖酐-40）中，一般来说，浓度增加时凝固性降低。在高分子血浆扩容剂（6%HES和6%右旋糖酐-70）中，低浓度和高浓度时凝固性略有增加，而中间浓度时凝固性降低。结论是，在临床上血液中使用浓度低于20%时，血浆扩容剂的TEG变化最小且无临床意义。
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