Hayes A G, Hawcock A B, Hill R G
Life Sci. 1984 Oct 8;35(15):1561-8. doi: 10.1016/0024-3205(84)90354-0.
The effect of capsaicin on the isolated sciatic nerve of rat was studied by extracellular recording of membrane polarisation. Capsaicin depolarised the sciatic nerve, but desensitization occurred rapidly upon repeated administration. Several other neuroactive substances, including substance P, were inactive. The depolarisation was reduced in nerves depleted of unmyelinated fibres by neonatal capsaicin treatment, suggesting that it occurs mainly in C-fibres. This depolarising action of capsaicin could explain the irritant and acute antinociceptive properties of capsaicin.
通过细胞外记录膜极化研究了辣椒素对大鼠离体坐骨神经的作用。辣椒素使坐骨神经去极化，但重复给药后脱敏迅速发生。包括P物质在内的其他几种神经活性物质无活性。新生大鼠经辣椒素处理后，无髓纤维缺失的神经去极化作用减弱，提示该作用主要发生在C纤维。辣椒素的这种去极化作用可以解释其刺激性和急性抗伤害感受特性。
