Hess P, Lansman J B, Tsien R W
Nature. 1984;311(5986):538-44. doi: 10.1038/311538a0.
Single cardiac transmembranous Ca channels have three modes of gating behaviour in the absence of drugs, expressed as current records with brief openings (mode 1), with no openings because of channel unavailability (mode 0 or null mode) and with long-lasting openings and very brief closings that appear only rarely (mode 2). The dihydropyridine Ca agonist Bay K 8644 enhances Ca channel current by promoting mode 2, while the Ca antagonists nitrendipine and nimodipine inhibit the current by favouring mode 0.
在无药物作用时，单个心脏跨膜钙通道有三种门控行为模式，表现为电流记录中出现短暂开放（模式1）、因通道不可用而无开放（模式0或零模式）以及出现仅偶尔发生的持久开放和非常短暂关闭（模式2）。二氢吡啶类钙激动剂Bay K 8644通过促进模式2来增强钙通道电流，而钙拮抗剂尼群地平和尼莫地平则通过促进模式0来抑制电流。
