Dubé J Y, Frenette G, Tremblay Y, Bélanger A, Tremblay R R
Prostate. 1984;5(5):495-501. doi: 10.1002/pros.2990050505.
During the course of another investigation, three dogs had been castrated 3 months previously. Upon completion of the experiment, it was discovered that one dog presented a spontaneous prostatic adenocarcinoma of intraalveolar proliferative type at histology. Prostate weight of this dog before castration was estimated to be 22 g by tridimensional measurement at laparotomy and remained relatively constant (19 g) 3 months after castration. These results indicate that if regression had occurred in some cell populations (androgen-dependent) it was only partial and masked by growth of androgen-independent cells. Analysis of 12 individual steroids in peripheral blood and in prostatic tissue attested of a normal adrenal secretory activity. A series of 15 hydrolytic enzymes along with receptors for androgen, estrogen, and progesterone, were determined in prostatic tissue obtained at sacrifice. Enzymatic activities were those of typical epithelial cells, and most of them remained relatively high despite low levels of circulating testosterone. However, two markers of androgen action in dog prostate, acid phosphatase and arginine esterase, were significantly reduced. Receptor levels were similar to those of castrated animals. Thus, cancer cells had probably retained some androgen sensitivity.
在另一项研究过程中，三只狗在三个月前接受了去势手术。实验结束时，组织学检查发现其中一只狗出现了肺泡内增殖型自发性前列腺腺癌。通过剖腹手术时的三维测量，这只狗去势前前列腺重量估计为22克，去势三个月后仍相对稳定（19克）。这些结果表明，如果某些细胞群体（雄激素依赖性）发生了消退，那也只是部分消退，并且被雄激素非依赖性细胞的生长所掩盖。对周边血液和前列腺组织中12种个体类固醇的分析证明肾上腺分泌活动正常。在处死后获取的前列腺组织中测定了一系列15种水解酶以及雄激素、雌激素和孕激素的受体。酶活性是典型上皮细胞的活性，尽管循环睾酮水平较低，但大多数酶活性仍相对较高。然而，狗前列腺中雄激素作用的两个标志物，酸性磷酸酶和精氨酸酯酶，显著降低。受体水平与去势动物相似。因此，癌细胞可能保留了一些雄激素敏感性。
