Dubé J Y, Frenette G, Tremblay R R, Tremblay Y, Bélanger A
Prostate. 1984;5(4):417-23. doi: 10.1002/pros.2990050406.
Eight dogs with spontaneous benign prostatic hyperplasia were treated with daily subcutaneous injections of 25 micrograms of Buserelin, (D-Ser(TBU)6,des-Gly-NH2(10))ethylamide during 3 months. Prostate weight before treatment was estimated by tridimensional measurements during open surgery. After 3 months of treatment, prostate weight was decreased by 50-60% In two castrated control animals, prostate weight decreased about 70% after 3 months. Histological pattern in prostates from castrated or Buserelin-treated animals was similar and indicated considerable atrophy of glandular epithelium and predominance of stroma. At the same time, testes weight decreased with complete disappearance of spermatogenic activity. Acid phosphatase and arginine esterase activity levels, two markers of androgenic action in the prostate, were similar after Buserelin or castration. Steroid receptors for androgens, estrogens, and progesterone also behaved similarly under the influence of Buserelin and castration.
八只患有自发性良性前列腺增生的狗，在三个月的时间里，每天皮下注射25微克的布舍瑞林（D - Ser(TBU)6,des - Gly - NH2(10))乙酰胺）进行治疗。治疗前前列腺重量通过开放手术中的三维测量来估计。治疗3个月后，前列腺重量减少了50 - 60%。在两只去势对照动物中，3个月后前列腺重量减少了约70%。去势或布舍瑞林治疗动物的前列腺组织学模式相似，显示腺上皮显著萎缩且基质占优势。同时，睾丸重量下降，生精活性完全消失。布舍瑞林治疗或去势后，酸性磷酸酶和精氨酸酯酶活性水平（前列腺中雄激素作用的两个标志物）相似。雄激素、雌激素和孕激素的类固醇受体在布舍瑞林和去势的影响下也表现相似。
