阿司匹林和对乙酰氨基酚对梨形四膜虫GL生长及大分子合成的影响。
The effects of aspirin and acetaminophen on tetrahymena pyriformis GL growth and macromolecular synthesis.
作者信息
Okano C K, Hokama Y, Chou S C
出版信息
Res Commun Chem Pathol Pharmacol. 1984 Aug;45(2):293-6.
The effect of aspirin and acetaminophen on Tetrahymena pyriformis GL is examined in this study. The concentration of drug which inhibited T. pyriformis GL growth in 24 hours, indicated as IC50, was 200 micrograms/ml and 580 micrograms/ml for aspirin and acetaminophen, respectively. Macromolecular incorporation study showed that aspirin at 100 micrograms to 400 micrograms/ml had essentially no effect on all parameters examined. Acetaminophen had a significant (P less than 0.01) suppression of 14C-thymidine, 14C-uridine and 14C-acetate uptake, but no effect on 14C-amino acid uptake at concentrations from 400 micrograms to 1200 micrograms/ml. T. pyriformis GL is a useful eukaryocytic single cell organism for drug action study.
本研究考察了阿司匹林和对乙酰氨基酚对梨形四膜虫GL的作用。在24小时内抑制梨形四膜虫GL生长的药物浓度，即IC50，阿司匹林为200微克/毫升，对乙酰氨基酚为580微克/毫升。大分子掺入研究表明，100微克至400微克/毫升的阿司匹林对所有检测参数基本无影响。对乙酰氨基酚在400微克至1200微克/毫升浓度下对14C-胸苷、14C-尿苷和14C-乙酸盐的摄取有显著抑制作用（P小于0.01），但对14C-氨基酸摄取无影响。梨形四膜虫GL是用于药物作用研究的有用真核单细胞生物。
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