Conklin K A, Lau S S
Anesthesiology. 1984 Jul;61(1):78-82.
The effects of halothane on uptake and phosphorylation of uridine, and on cellular ATP content were studied in Tetrahymena pyriformis, a ciliate protozoan. Exposure to halothane inhibited the accumulation of 14C-uridine into the following acid-soluble intracellular pools: UTP, UDP, UMP, and an unidentified compound. Halothane did not alter ATP content of intact cells. It is concluded that inhibition by halothane of uridine incorporation into RNA of T. pyriformis is due to effects on uridine uptake and/or phosphorylation and not due to inhibition of the RNA polymerase reaction or reduction of ATP content.
在梨形四膜虫（一种纤毛原生动物）中研究了氟烷对尿苷摄取、磷酸化以及细胞ATP含量的影响。暴露于氟烷会抑制14C-尿苷积累到以下酸溶性细胞内池：UTP、UDP、UMP和一种未鉴定的化合物。氟烷不会改变完整细胞的ATP含量。得出的结论是，氟烷对梨形四膜虫RNA中尿苷掺入的抑制作用是由于对尿苷摄取和/或磷酸化的影响，而不是由于RNA聚合酶反应的抑制或ATP含量的降低。
