Gaertner H J, Flössel C, Müller M
Biomed Biochim Acta. 1984;43(4):429-38.
Guinea pig peritoneal macrophages and blood monocytes possess a membrane-bound tissue factor-like procoagulant activity. This activity can be induced to grow by mitogenic lectins and by lymphocyte products released specifically upon contact with immunizing antigens in vitro. The procoagulant activity can be easily measured by a plasma recalcification test. Guinea pig peritoneal cells and mononuclear blood cells from animals immunized with ovalbumin, bovine gamma-globulin or tetanus vaccine reacted to the corresponding antigen in a specific manner by expression of increased amounts of procoagulant activity (ovalbumin: + 16.9%; bovine gamma-globulin: + 26.8%, tetanus vaccine: + 23.5%). Supernatants from peritoneal cells were active in transferring the stimulus to neutral peritoneal cells which expressed thereafter higher amounts of procoagulant activity.
豚鼠腹腔巨噬细胞和血液单核细胞具有一种膜结合的组织因子样促凝活性。这种活性可被促有丝分裂凝集素以及体外与免疫抗原接触时特异性释放的淋巴细胞产物诱导增强。促凝活性可通过血浆复钙试验轻松测定。用卵清蛋白、牛γ球蛋白或破伤风疫苗免疫的动物的豚鼠腹腔细胞和单核血细胞，通过表达增加量的促凝活性，以特异性方式对相应抗原作出反应（卵清蛋白：+16.9%；牛γ球蛋白：+26.8%，破伤风疫苗：+23.5%）。腹腔细胞的上清液能有效地将刺激传递给中性腹腔细胞，后者随后表达出更高量的促凝活性。
