Huntley J, Newby T J, Bourne F J
Immunology. 1979 May;37(1):225-30.
The immune response of pigs to oral immunization with dinitrophenylated bovine gamma globulin (DNP-BGG) was assessed using the indirect macrophage migration assay. Two days' exposure to the antigen resulted in the inhibition of macrophage migration by supernatants of cultures from the intestine but not the mesenteric lymph node or spleen. Stimulation for 7 days resulted in macrophage inhibition by supernatants of lymphocyte cultures prepared from the intestine, mesenteric lymph node and spleen. Supernatants of splenic lymphocytes from animals stimulated for 2 or 3 days produced enhancement of macrophage migration.
使用间接巨噬细胞迁移试验评估猪对二硝基苯基化牛γ球蛋白(DNP-BGG)口服免疫的免疫反应。接触抗原两天后,肠道培养上清液可抑制巨噬细胞迁移,但肠系膜淋巴结或脾脏培养上清液无此作用。刺激7天后,肠道、肠系膜淋巴结和脾脏制备的淋巴细胞培养上清液可抑制巨噬细胞迁移。刺激2或3天的动物脾脏淋巴细胞培养上清液可增强巨噬细胞迁移。