Proffitt R, Case R M
Cell Calcium. 1984 Aug;5(4):321-34. doi: 10.1016/0143-4160(84)90001-0.
The effects of vanadate on calcium homeostasis and enzyme secretion have been assessed in the incubated pancreas of young rats. Vanadate causes an acceleration of 45Ca efflux from pre-loaded uncinate glands; amylase release is reversibly increased for the duration of exposure to vanadate. Alkaline orthovanadate is most effective in eliciting these responses; its effects are greatly reduced at pH 7.4. However, changes in pH alone do not mimic these effects. Other vanadium oxides (meta-vanadate, vanadium pentoxide and vanadyl sulphate) are poor secretagogues. Alkaline ortho-, or meta-vanadate also causes an increased calcium uptake although this does not seem to be responsible for the observed secretory response. Vanadate is thought to stimulate pancreatic secretion by an effect on intracellular calcium store(s).
钒酸盐对幼鼠离体胰腺钙稳态和酶分泌的影响已得到评估。钒酸盐可使预先加载的钩突腺中45Ca外流加速；在接触钒酸盐的期间，淀粉酶释放可逆性增加。碱性原钒酸盐在引发这些反应方面最为有效；在pH 7.4时其作用大大减弱。然而，仅pH变化并不能模拟这些作用。其他钒氧化物（偏钒酸盐、五氧化二钒和硫酸氧钒）促分泌作用较弱。碱性原钒酸盐或偏钒酸盐也会使钙摄取增加，尽管这似乎并非观察到的分泌反应的原因。钒酸盐被认为是通过对细胞内钙库的作用来刺激胰腺分泌的。
