Munir K M, Nair J, Bhide S V
Carcinogenesis. 1984 Nov;5(11):1519-21. doi: 10.1093/carcin/5.11.1519.
Comparative formation of chlorophenol metabolites were evaluated in hexachlorocyclohexane (HCH) fed mouse and rat livers by h.p.l.c. No significant species differences were noted in the formation of chlorophenol metabolites studied both in vivo and in vitro. The results indicate that the marked species difference that is observed in tumor induction between mice and rats by HCH may not be due to the different rate of formation of chlorophenol metabolites.
通过高效液相色谱法评估了在喂食六氯环己烷（HCH）的小鼠和大鼠肝脏中氯酚代谢物的比较形成情况。在体内和体外研究的氯酚代谢物形成过程中，未观察到明显的物种差异。结果表明，HCH在小鼠和大鼠之间诱导肿瘤时观察到的显著物种差异可能不是由于氯酚代谢物形成速率的不同。
