Oblin A, Zivkovic B, Bartholini G
Eur J Pharmacol. 1984 Oct 1;105(1-2):175-7. doi: 10.1016/0014-2999(84)90664-2.
Repeated treatment with, but not single administration of drugs which impair dopaminergic transmission produced a consistent reduction in substance P immunoreactivity in the rat substantia nigra. This effect appears to be related to the D-2 dopamine receptor function as the blockade of this receptor subtype by selective antagonists produced effects qualitatively similar to those produced by drugs lacking selectivity for different subclasses of dopamine receptors.
反复给予而非单次给予损害多巴胺能传递的药物，会使大鼠黑质中P物质免疫反应性持续降低。这种效应似乎与D-2多巴胺受体功能有关，因为选择性拮抗剂对该受体亚型的阻断所产生的效应，在性质上与缺乏多巴胺受体不同亚类选择性的药物所产生的效应相似。
