Sonsalla P K, Gibb J W, Hanson G R
Eur J Pharmacol. 1984 Oct 1;105(1-2):185-7. doi: 10.1016/0014-2999(84)90666-6.
The roles of different dopamine receptors in mediating the responses of the striato-nigral substance P (SP) feedback loop were investigated. Subacute treatment of rats with the D1 agonist, SK&F 38393, produced a significant decrease in SP content in the substantia nigra whereas treatment with the D2 agonist, RU 24926, elevated nigral SP concentrations. Consequently, the elevation in nigral SP content which occurs following treatment with methamphetamine is likely a D2-mediated event. This conclusion is supported by our observation that the D2 antagonist, sulpiride, totally blocked the methamphetamine effect. These findings suggest that D1 and D2 receptors mediate opposing influences on the SP feedback system.
研究了不同多巴胺受体在介导纹状体 - 黑质P物质（SP）反馈回路反应中的作用。用D1激动剂SK&F 38393对大鼠进行亚急性治疗，可使黑质中SP含量显著降低，而用D2激动剂RU 24926治疗则可提高黑质中SP浓度。因此，用甲基苯丙胺治疗后黑质中SP含量的升高可能是由D2介导的事件。我们观察到D2拮抗剂舒必利完全阻断了甲基苯丙胺的作用，这一结论得到了该观察结果的支持。这些发现表明，D1和D2受体对SP反馈系统介导相反的影响。
