新型β2选择性肾上腺素能受体兴奋剂克仑特罗对被动致敏豚鼠肺组织匀浆中组胺和慢反应物质A释放的影响

Effect of clenbuterol, a new beta 2 selective adrenoceptor stimulant, on the release of histamine and SRS-A from passively sensitized guinea-pig chopped lungs.

作者信息

Yamazaki N, Hosoki R, Takayanagi I

出版信息

Gen Pharmacol. 1984;15(4):345-8. doi: 10.1016/0306-3623(84)90012-0.

DOI:10.1016/0306-3623(84)90012-0

Abstract

Effect of clenbuterol on the release of histamine and SRS-A from passively sensitized guinea-pig lungs was studied in a superfused-cascade bioassay system, and compared with isoproterenol and salbutamol. One-week-old guinea-pig lungs were used, since histamine and SRS-A were released more in these than in 6- or 12-week old lungs during anaphylaxis. Clenbuterol, isoproterenol and salbutamol (10(-8) - 10(-7) M) were found to inhibit the releases of histamine and SRS-A. These actions were inhibited by propranolol. These results suggest that clenbuterol inhibits the releases of histamine and SRS-A via the beta-adrenoceptor.

摘要

在一个灌流级联生物测定系统中研究了克仑特罗对被动致敏豚鼠肺中组胺和慢反应物质A（SRS-A）释放的影响，并与异丙肾上腺素和沙丁胺醇进行了比较。使用一周龄豚鼠的肺，因为在过敏反应期间，这些豚鼠肺中组胺和SRS-A的释放比6周龄或12周龄豚鼠肺中的释放更多。发现克仑特罗、异丙肾上腺素和沙丁胺醇（10^(-8)-10^(-7)M）可抑制组胺和SRS-A的释放。这些作用被普萘洛尔抑制。这些结果表明，克仑特罗通过β-肾上腺素能受体抑制组胺和SRS-A的释放。

相似文献

1

Effect of clenbuterol, a new beta 2 selective adrenoceptor stimulant, on the release of histamine and SRS-A from passively sensitized guinea-pig chopped lungs.新型β2选择性肾上腺素能受体兴奋剂克仑特罗对被动致敏豚鼠肺组织匀浆中组胺和慢反应物质A释放的影响

Gen Pharmacol. 1984;15(4):345-8. doi: 10.1016/0306-3623(84)90012-0.

2

Effects of formoterol (BD 40A), a beta-adrenoceptor stimulant, on isolated guinea-pig lung parenchymal strips and antigen-induced SRS-A release in rats.β-肾上腺素能兴奋剂福莫特罗（BD 40A）对豚鼠离体肺实质条及大鼠抗原诱导的慢反应物质A释放的影响。

Arch Int Pharmacodyn Ther. 1984 Jan;267(1):91-102.

3

Pulmonary anti-anaphylactic activity of clenbuterol tested on actively and passively sensitized guinea-pigs.在主动和被动致敏豚鼠身上测试的克伦特罗的肺部抗过敏活性。

Eur J Pharmacol. 1985 Dec 17;119(3):169-76. doi: 10.1016/0014-2999(85)90292-4.

4

Effect of fenoterol on immunological release of leukotrienes and histamine from human lung in vitro: selective antagonism by beta-adrenoceptor antagonists.非诺特罗对人肺组织体外白三烯和组胺免疫释放的影响：β-肾上腺素能受体拮抗剂的选择性拮抗作用

Eur J Pharmacol. 1983 Nov 25;95(3-4):239-45. doi: 10.1016/0014-2999(83)90640-4.

5

Effect of coenzyme Q10, a quinone derivative, on guinea pig lung and tracheal tissue.

Arzneimittelforschung. 1985;35(6):929-33.

6

Anti-allergic activity of formoterol, a new beta-adrenoceptor stimulant, and salbutamol in human leukocytes and human lung tissue.新型β-肾上腺素能受体激动剂福莫特罗与沙丁胺醇在人白细胞和人肺组织中的抗过敏活性。

Allergy. 1983 Nov;38(8):547-52. doi: 10.1111/j.1398-9995.1983.tb04138.x.

7

Effect of butyl 3-(1H-tetrazol-5-Yl) oxanilate (MTB) on immunological or non-immunological histamine and SRS(-A) release from guinea-pig, monkey and human lung tissue.3-(1H-四氮唑-5-基)氧代苯甲酸丁酯（MTB）对豚鼠、猴和人肺组织中免疫性或非免疫性组胺及慢反应物质（SRS-A）释放的影响。

Jpn J Pharmacol. 1987 Aug;44(4):447-53. doi: 10.1254/jjp.44.447.

8

Potential anti-anaphylactic activity of clenbuterol, a beta-agonist with calcium antagonist properties.克伦特罗（一种具有钙拮抗剂特性的β-受体激动剂）的潜在抗过敏活性。

Agents Actions. 1985 Apr;16(3-4):166-9. doi: 10.1007/BF01983129.

9

Computerization of a bioassay: quantitation of slow reacting substance of anaphylaxis (SRS-A).生物测定的计算机化：过敏反应慢反应物质（SRS-A）的定量分析

J Pharmacol Exp Ther. 1979 May;209(2):238-43.

10

Effects of sodium cromoglycate analogues on the immunological release of slow reacting substance of anaphylaxis and histamine from human and guinea-pig lung in vitro.色甘酸钠类似物对人及豚鼠肺组织在体外免疫释放过敏反应慢反应物质和组胺的影响。

J Pharm Pharmacol. 1982 Jun;34(6):401-2. doi: 10.1111/j.2042-7158.1982.tb04741.x.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。